The Red Devils’ two goals were scored by Amr El Sulaya and Mohamed ‘Afsha’ Magdi, while Mahmoud Shikabala netted the White Knights’ first-half equalising goal.
Mosimane was hoping to become the eighth coach to win more than one Caf Champions League title having clinched his maiden trophy during his time with Mamelodi Sundowns in 2016.
The South African tactician recalled Amr El Sulaya to the starting line-up after the influential midfielder was rested as the Red Devils defeated Abu Qair Semad 2-1 in the Egyptian Cup match last weekend.
Mahmoud Abdelrazek Hassan Fadlala, who was part of the last Zamalek team to win the Champions League title in 2002, started for the White Knights.
Better known as Shikabala, Fadlala was also a key member of the White Knights side which was defeated by Mosimane’s Sundowns in the 2016 final.
The Red Devils got off to a dream start as they grabbed an early goal through El Sulaya after the White Knights’ defence caught ball watching.
Ali Maaloul, who was also recalled to the starting line-up by Mosimane, delivered a well-taken corner-kick which was headed home by El Sulaya to make it 1-0 to Al Ahly in the fifth minute.